Pueraria Mirifica has grown for centuries in Northern Thailand certainly is a miracle plant. Its very powerful estrogenic effects has the power to make many of the pharmaceutical companies who manufacture prescription estrogen products for various uses quiver. Pueraria Mirifica is agonistic for calcium.1 It has been used safely in various parts of Asia for centuries and its benefits as an anti-aging remedy have lived up to the folklore! Pueraria mirifica is very close to being the "Fountain of Youth." The broad based phytoestrogen complex in Pueraria Mirifica far exceeds all other plant supplements. The dominant driving estrogenic compounds mimic 17 beta estradiol with some very, very distinct differences. Unlike 17 beta estradiol, deoxmiroestrol and miroestrol are not steroidal compounds. The actives in Pueraria Mirifica
extracts are not mutagenic nor do they cause proliferation of cells in Mcf 7 platings2 nor has it in animal studies done in England in the early 1960's.3 Recently a Korean group isolated a fraction from Pueraria Mirifica called spinosterols which had a significant anti-proliferative effect on breast cancer cell lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T.4 One of these spinosterol fractions affected the growth (inhibitory) of some breast cancer cell lines (MCF-7, MDAMB- 231) in a dose- and time-dependent manner, as well as the growth of ovarian (2774) and cervical cancer cells (HeLa).4
Another recent study study by a Thai-Japanese team has discovered very compelling and powerful implications for men. It had previously been thought that because of deoxymiroestrol and miroestrol's unique efficacy mature men could use it only sparingly. This recent study (animal) demonstrates that it takes a great deal of Pueraria Mirifica to effect the androgenic-hypothalamic axis. This has profound anti-aging implications for men.5
Table 1.Chromene,isoflavonoid,and coumestran derivatives in Pueraria Mirifica The complex dynamic of high quality Pueraria Mirifica (Pueraraprem)
Cultivars: Premium Pueraria Mirifica (Pueraraprem)| Premium Butea Superba (Buteaprem) |
American Phyto Lab : raw materials for supplement and cosmetic
A word about Butea Superba
There are many species of Butea Superba and many species coming out of the wild. Our cultivar (Buteaprem TM ) has been developed by our research staff from several select species. Of course not all of these species are created equal. Marketers want to make and sell Butea Superba products for men. It is unfortunate that they are purchasing the lowest quality material available coming in from Thailand. These wild materials are acquired in the jungles by villagers. Butea Superba is similar to Pueraria Mirifica and Korean Ginseng in the sense that they really need to grow for many years to achieve any real efficacy. Most of the Pueraria Mirifica and Butea Superba is harvested in remote locations. If it is not processed and desiccated rapidly the actives that are in the plant begin to oxidize.
What Thai companies have elected to do is make extracts out of these inferior wild materials. It sounds impressive 4:1, 10:1, 30:1, 120:1 etc. Unfortunately much of the older growth wild Butea Superba and Pueraria Mirifica has been harvested years ago. It is human nature to think in terms of yearly harvests. Unfortunately a 6 month old or even a 4 year old plant may contain no actives at all: well , 4 x 0 =0, 10 x 0= 0, 30 x 0= 0, 100 x0 = 0. Do you get the message? Where 0 = actives. Many herbal enthusiasts selling low quality Butea Superba make a lot of ridiculous exaggerations and claims. Butea Superba has several physiological functions. Broadly It is a tonic and has been found to be anabolic. Animal studies show increases in luteinizing hormone and follicle stimulating (associated with increased sperm production in men). Some Butea Superba is relatively high in novel Flavonoids and Flavonoid Gycosides. Research has demonstrated potent phosphodiesterase inhibitory effects. In a recent study done with male human volunteers in Thailand using GC/MAS SPEC on urine samples with short term administration of Butea Superba researchers found increases of androstendione, testosterone, estradiol and estriol. Mild increases of Luteinizing Hormone were observed. There is an anabolic compound in the plant that that is similar to follicle stimulating hormone.
1. Hataitip Trisomboon, Suchinda Malaivijitnond, Juri Suzucki,Yuzuri Hamada, Gen Watanabe, and
2. W. Cherdshewasart , W. Cheewasopit , P. Picha , Journal of Ethnopharmacology 93 (2004) 255–260
Soo-Jong Um 7,11
Department of Bioscience and Biotechnology/Institute of Bioscience Sejong University
Chebigen Inc., 305-B, Chungmugwan Sejong University Seoul 143-747 Korea
Seohae Environment Science Institute Chonbuk National University Total Research Complex
11 Corresponding author: Tel, 82-2-3408-3641; Fax, 82-2-3408-3334; E-mail, firstname.lastname@example.org
5. Suchinda Malaivijitnond), Patthama Kiatthaipipat), Wichai Cherdshewasart), Gen Watanabe and
We manufacture supplement powder (with naturally occurring cellulose), extract powders (low ratios) cellulose removed for cosmetics and natural ratio extracts in propylene glycol and other solvents (special order). The actives in our products are significantly higher than wild extracts. Many wild supplement material contains little or no miroestrol and secondary actives profile is much lower. It is unlikely from the current quantitative studies down that wild supplement material has significant deoxymiroestrol. To insure high quality processing we utilize and maintain onsite desiccation equipment with controlled temperature. Materials are desiccated and processed immediately after harvest. This is a lengthy process and one of the keys for maximum actives. Our paradigms are far superior to sun-drying plants or transporting wild plants from remote locations to the city. Time = oxidation= less actives= no deoxymiroestrol. Superior processing means higher actives especially deoxymiroestrol which is quite volatile.
The complex dynamic of high quality Butea Superba (Buteaprem TM )
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