Miracle Herb Pueraria Mirifica (Pueraraprem) American Phyto Lab | Background


 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


  

 

 

 

 

 


 

 

 

 



 

 



 

 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 

 

 

 

 

 

 


 

 

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


 

 

 

 

 


 


 
 

 

                                                                                                                               Background


 


 

 

 

 


 




                                                             


 

Chemical Composition of Pueraria Mirifica

The compounds that make Pueraria mirifica different from any other plants in the Family Leguminosae are Miroestrol and Deoxymiroestrol, which possess highest activity among the known phytoestrogens due to the unique molecular geometry.  Miroestrol was the first compound isolated from this plant by a group of German chemists in 1940, but the plant had actually been mistakenly reported then as Butea superba. It was later reclassified as a new plant called Pueraria mirifica (Airy Shaw et Suvatabhandu).

In 1993  Dr. E. J. Corey (nobel prize laureate) and his graduate student Lawrence Wu at Harvard University were the first to synthesize the total miroestrol molecule. This was quite truly a complicated fete!  They also noticed a spike of a compound whose 500 MHz H NMR spectrum that was similar to the precursor synthetic intermediate of miroestrol (found in the total synthesis process). More recently this compound has been identified as the precursor deoxymiroestrol in the of the Journal of Natural Products. The authors proposed that since deoymiroestrol is easily oxidized to miroestrol it could be the dominant phytoestrogen making miroestrol simply an artifact.

It is currently accepted that the two phytoestrogens co-exist in the root of the plant.  A study using many samples derived from supplement material demonstrated  much variablity between samples.   In fact many of the samples contained no chromenes at all.   In all the samples that contained chromenes miroestrol was dominant in quantity, while deoxymoroestol was present in much lower.  Significant amounts of deoxymiroestrol were found in the higher quality samples tested. 

Processing techniques, inherent plant dynamics and farming vs wild plants is undoubtedly critical for viable deoxymiroestrol levels.

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As shown below the chemical structures of the two compounds are very similar to that of estradiol.

 

More than 20 kinds of chemical substances were analyzed from Pueraria Mirifica and they were divided in to 3 groups
1. A mild action of substances in the group of Sterol.  (beta-sitosterol, stigmasterol)
2. The substances in Isoflavanoid groups which also can be found in soybeans and other North American plants.

  3. The acute substances of the Coumestan group

Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, Thailand, July 2000

In addition to miroestrol and deoxymiroestrol, Pueraria mirifica contains other phytoestrogen compounds belonging to the isoflavone and coumestan groups (refer to the table on the home page).
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Revised: 08/20/2019
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