Miricle Herb Butea Superba (Buteaprem) Farmed cultivar by American Phyto Lab  






































































































































































































Flavonoid and Flavonoid Glycoside from Butea Superba Roxb and their cASVIP Phosphodiesterase Inhibitory Activity


Flavonoid(3,7,3'-trihydroy-4'-methoxyflavaone)(1) and flavonoid glycosides dihydoxy-4'-methuxyflavone-7-0-p.-D-glucopyranoside)  (2) were isolated from the roots of Butea Superba Roxb.  The structures were determined on the basis of spectral analysis 2d-nmr lechiik-lues.  These compounds show strong inhibitory effects on cAMD phospodiesterase.


Butea Superba Roxb. is a herb in the Family  Papilionaceae and has the characteristics of a crawer that wraps itself around large trees.  One branch has 3 leaves, the flowers are a yellowish color and the plant grow's out in the open.  The long roots of the plant are buried under the "the round like roots of the yam."  This type of plant reproduces through seeds and the separation of its roots.  This plant can be found growing in forests in the northern regions, in the eastern regions and along Karnchanaburi Province.  The roots  and stem of the plant are used for medicines for strength and power.  In addition, the roots and stem of the plant are considered to help increase male sexual performance. Thus, this plant has come to be known as one type of miracle herb.  The bioactivity of each constituent was tested, especially the cAMP phophodiesterase inhibitory effects in controlling a number of diseases(1).  Therefore, the research conducted was designed to test the hypothesis that the chemical constituents of this plant is actually capable in enhancing certain physiological functions.


From testing the bioactivity of Flavonoid and Flavonoid glycoside, it was found that both of these compounds were effective in inhibiting cAMP phosphodieterase. The result of inhibiting cAMP phosphodiesterase of both these compounds was greater than theophylline (IC50 =615 u.g/mL) and caffeine (IC50 = 420 u.g/rnL). The cAMP phosphodiesterase enzyme has a main function in the hydrolysis of the intracellular cAMP.  Some compounds  that inhibit cAMP phosphodiesterase are therefore capable of stimulating the functioning of the central nervous system (CNS) and stimulating the functioning of cells.


Butea superba Roxb- has a complex dynamic and has been shown effective in inhibiting the cAMP phosphodieslerase enzyme. The attributes of this herb in increasing male sexual performance is most probably due to inhibition of cAMP phosphodiesterase, elevations of androsteinedione and testosterone have been observed in 24 hour urine (Gc-Mass Spec). Studies have demonstrated that Butea Superba increases luteInizing hormone, and follicle stimulating hormone. It has been demonstrated in these same studies an androgenic effect as well as an anti-estrogenic effect. Once could speculate Butea Superba could help support heart health because of it's vasodilation properties. Phosphodiesterase inhibitors like caffeine have been linked with lower incidence of type 2 diabetes. In a joint effort between Thai scientist and scientists in the Netherlands the following anti-oxidant fractions have been identified in Butea Superba: procyanidin B2, (-)-epicatechin and procyanidin B5. Butea Superba also contains the sterol compounds beta-sitosterol, campesterol and stigmasterol. This may benefit men for prostrate support and cholesterol support.


Butea Superba is also known as Red Kwao Kreu which grows in the central, eastern, and northern regions of Thailand.  Butea Superba contains high flavonoids and flavonoid glycosides a c-AMD phospodiesterase inhibitor.  Many species of the plant exist. Through an arduous research effort two species were selected for commercial cultivation.  Although there are chemical similarities to Pueraria Mirfica (white kwao krua) the two plants are very diverse in their chemical attributes. With our research efforts it has been established that Butea Superba does facilitate vasodilation in the utilizing similar mechanisms as the precription drug Viagra.  Subjects also report an increase of energy without an increase in nervous system stimulation.  Butea Superba has been using safely with no known side effects.  This herb can be utilized as a mild alternative to drugs like viagra.  The delivery of  Butea Superba can be through oral ingestion capsules), sublinguals or a cosmetic topicals.







The process starts with the brain registering a sexual stimulus. The brain then  orchestrates a cascade of nerve signals that run through the spinal cord to the penis. Here, the cavernosal nerves release nitric oxide, a gas that quickly penetrates the  smooth muscle cells that form the penis spongy tissue. The nitric oxide causes  the cells to produce a substance called the cyclic guanine mono phosphate  (cGMP), which has an expansive, relaxing effect.

                        Parasympathetic Stimulaion

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                               Nitric Oxide Release

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                       Guanylate monophosphate (cGMP)

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 Smooth muscle relaxation in the corpus corpus cavernosum


The arteries feeding the penis expand and the smooth muscle relaxes, opening up tiny sacs in the erectile tissue that then swell with blood. The two main chambers of the penis, the corpus cavernosum, fill and the organ becomes so engorged that the veins that usually drain away blood are pressed shut against the tough outer membrane of the erectile chambers. The result is erection. Flavonoid and Flavonoid glycoside from Butea Superba Roxb and their cASVIP Phosphodieterase Inhibitory Activity.      


                                                                                                 What is Butea Superba?





                                                              “Normal Physiologic  Mechanism Leading to Erection”  




Copyright © 2002 [Cultivars Premium Pueraria Mirifica/ Butea Superba]
All rights reserved American Phyto Lab
Revised: 05/20/2011